predictive value of tissue inhibitor of metalloproteinases-1 and carcinoembryonic antigen plasma levels in response to chemotherapy in patients with metastatic colorectal cancer
نویسندگان
چکیده
background: colorectal cancer is one of the most important causes of morbidity and mortality in the world. it has been suggested that tissue inhibitor of metalloproteinase-1 (timp-1) plays a particular role in cancer promotion. the objective of the present study was to compare the effect of repeated measurement of carcinoembryonic antigen (cea) and timp-1 plasma levels in a follow-up response to chemotherapy treatment in patients with unresectable metastatic colorectal cancer by surgery. materials and methods: all consecutive patients between 18 and 75 years old in both genders with rectal adenocarcinoma who referred to sayed al-shohada medical center, during 6 months of study period enrolled in the study. level of cea and timp-1 were assessed before and after two cycles of chemotherapy. furthermore, patients underwent computed tomography scan to assess response to chemotherapy. the sensitivity, specificity, and areas under the receiver operating characteristic curves (auc) calculated for baseline level of cea and timp. results: the mean age of the studied patients was 52.7 } 7.5 years, 12 patients (48%) were male. response to chemotherapy after two cycles was 80%. in patients who responded to chemotherapy level of timp after treatment was significantly decreased compared to before treatment ( p < 0.0001). before and after treatment in patients who responded to chemotherapy the level of timp was significantly lower than who did not response to chemotherapy ( p < 0.05). the critical values for the prediction response to chemotherapy for cea was >63 (auc: 0.54) and for timp was ?8823 (auc: 0.68). conclusion: the present study has identified a strong significant association between high plasma timp-1 levels and short survival in patients with colorectal cancer. in addition, results demonstrated that the timp-1 provides stronger prognostic information than cea.
منابع مشابه
Predictive value of tissue inhibitor of metalloproteinases-1 and carcinoembryonic antigen plasma levels in response to chemotherapy in patients with metastatic colorectal cancer
BACKGROUND Colorectal cancer is one of the most important causes of morbidity and mortality in the world. It has been suggested that tissue inhibitor of metalloproteinase-1 (TIMP-1) plays a particular role in cancer promotion. The objective of the present study was to compare the effect of repeated measurement of carcinoembryonic antigen (CEA) and TIMP-1 plasma levels in a follow-up response to...
متن کاملValue of tissue carcinoembryonic antigen in patients with colorectal carcinoma.
The tumours of 55 patients with colorectal carcinoma were evaluated for tissue carcinoembryonic antigen (CEA) by immunoperoxidase staining. It was shown that 33/35 patients with increased preoperative serum CEA levels above 5 ng/ml had positive tissue CEA. The other 17/20 patients who had serum CEA levels less than 5 ng/ml could be demonstrated CEA in tissue. The results of tissues CEA were com...
متن کاملPrimary tumor levels of tissue inhibitor of metalloproteinases-1 are predictive of resistance to chemotherapy in patients with metastatic breast cancer.
PURPOSE Only about 50% of metastatic breast cancer patients benefit from cytotoxic chemotherapy. Today, no validated markers exist for prediction of chemotherapy sensitivity/resistance in this patient group. Tissue inhibitor of metalloproteinases-1 (TIMP-1) has been shown to protect against apoptosis, and the purpose of the present study was to test the hypothesis that tumors expressing high le...
متن کاملComparison of carcinoembryonic antigen prognostic value in serum and tumour tissue of patients with colorectal cancer
OBJECTIVE Carcinoembryonic antigen (CEA) in the serum and the tumour tissue of colorectal cancer (CRC) patients is the most commonly used tumour marker for the diagnosis and evaluation of prognosis or recurrence after treatment, but the role remains controversial. The objective of this study was to compare the prognostic value of CEA both in serum and tumour tissue in CRC. METHOD A total of 1...
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عنوان ژورنال:
journal of research in medical sciencesجلد ۱۹، شماره ۱۲، صفحات ۰-۰
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